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Particle Analysis / Laser Particle Size Analysis

Bettersizer 2600 Plus

Laser Diffraction
PIC-1 Dynamic Imaging
ISO 13320
0.02–3,500 µm
21 CFR Part 11

Combines laser diffraction with the PIC-1 dual-camera dynamic image analysis module in a single platform. Measures particle size and 24 shape parameters simultaneously from 0.02 to 3,500 µm. Wet and dry dispersion modules provide full flexibility for any sample type.

Request a Quote → Technical Specifications
Bettersizer 2600 Plus
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0.02–3,500 µm
Total range (LD + PIC-1)
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92 detectors
Scattering angle 0.016°–165°
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70 fps
PIC-1 dual-camera imaging
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<0.5% CV
Repeatability, <10 sec measurement
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24 parameters
PIC-1 shape analysis
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ISO 13320
Laser diffraction compliance
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ISO 13322-2
Dynamic image analysis compliance
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21 CFR Pt.11
Pharmaceutical GMP / USP <429>
Bettersizer 2600 Plus — Wet and Dry Dispersion

Laser Diffraction System

92 Detectors, 0.016°–165° Angular Range

A 92-detector array with Mie and Fraunhofer optical models delivers fast, repeatable particle size distributions across a wide angular range. Covers 0.02–2,600 µm; extended to 3,500 µm when the PIC-1 module is active.

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92 Spherical Photodetectors
Simultaneously captures scattered light across 0.016° to 165°, enabling wide dynamic range in a single measurement.
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Mie and Fraunhofer Models
Both optical evaluation models are supported; the appropriate one is selected based on sample optical properties.
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Wet and Dry Dispersion
Modular design allows switching between liquid and dry dispersion units from within the software.
Bettersizer 2600 Plus — PIC-1 Dynamic Imaging Module

PIC-1 Dynamic Imaging Module

24 Shape Parameters, Dual-Camera System

The PIC-1 module captures high-speed particle images during measurement and combines morphology data with laser diffraction results in a single report. Runs simultaneously with laser diffraction or independently.

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1.5 MP CMOS, 70 fps
High-speed dual cameras measure 24 shape descriptors including circularity, convexity, and sphericity.
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Combined or Independent Mode
Operates alongside laser diffraction or as a standalone imaging mode — selectable from software.
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Agglomerate Detection
Visualises agglomerates, irregular particles, and coarse-fraction tails that laser diffraction alone cannot resolve.

Frequently Asked Questions

What You Wonder About

Laser diffraction covers 0.02–2,600 µm. With the PIC-1 dynamic imaging module active, the total range extends to 3,500 µm. A single instrument therefore covers fine particles through to the coarse-fraction tail.

Laser diffraction (LD) delivers volumetric size distributions rapidly and with high repeatability but does not directly measure particle shape. Dynamic image analysis (DIA) captures individual particle images and quantifies morphology as 24 shape descriptors. The Bettersizer 2600 Plus applies both techniques in the same measurement and combines them in a single report.

Wet: BT-812, BT-80N Pro, BT-80N, and BT-814. Dry: BT-912 and BT-903. The appropriate unit is chosen based on sample type, solvent compatibility, and volume. Switching is done from the software without tools.

PIC-1 measures 24 shape descriptors including length, width, equivalent circle diameter, aspect ratio, circularity, convexity, sphericity, and compactness. Results appear alongside laser diffraction size data in the same report.

ISO 13320 (laser diffraction), ISO 13322-2 (dynamic image analysis), USP <429>, and 21 CFR Part 11 (electronic records and signatures). This compliance scope enables direct use in pharmaceutical GMP environments.

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